|Awarded On||November 19, 2015|
|Title||Role of PARP-1 in Estrogen Receptor Enhancer Function and Gene Regulation Outcomes in Breast Cancers|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||W. Lee Kraus|
Breast cancer is the second leading cause of cancer-related mortality in women, with a 1 in 8 lifetime of risk for women in the United States. A key hurdle in developing better treatments for breast cancers is a lack of understanding of the mechanisms that promote the growth of breast cancer cells, and why some breast cancers grow in response to estrogens, while others do not. Drugs that target PARP-1, a protein involved in many important cellular functions, have shown promise and may be useful for treating estrogen receptor alpha (ERa)-positive breast cancers. In this regard, we have been studying the interplay between ERa and PARP-1 in breast cancers. Specifically, we are focusing on th...