|Awarded On||November 19, 2015|
|Title||Mechanisms and targeting strategies for SWI/SNF mutations in cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Xuetong Shen|
|Cancer Sites||Breast, Gallbladder, Liver and Intrahepatic Bile Duct, Ovary, Pancreas, Prostate|
The Cancer Genome Atlas (TCGA) projects have revealed many important mutations in human cancers. Among them, mutations in the subunits of SWI/SNF chromatin remodeling complex show strikingly high prevalence in a wide spectrum of human cancers, collectively occurring in 20% of all human cancers. For example, mutations in the core subunit of Snf2/Brg1 are found in almost 100% of small cell ovarian cancer. Given the high frequency of SWI/SNF mutations in human cancers, an important question of high research priority is: Can we understand these mutations and make use of our findings in cancer treatment? To answer this question, in this application, we propose to take a comprehensive approach by ...