Grant ID RP160235
Awarded On November 19, 2015
Title Regulation of tumor aggressiveness and immune suppression in lung adenocarcinoma
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Health Science Center at Houston
Principal Investigator/Program Director Qingyun Liu
Cancer Sites Lung and Bronchus
Contracted Amount $900,000
Lay Summary

Lung cancer remains the leading cause of cancer related death in the world. Recent progress in the development of targeted therapeutics against mechanisms that drive the formation and growth of a subset of lung adenocarcinoma has provided breakthrough treatment to those patients. However, the vast majority of lung cancer cases still don’t have targeted therapies available. Recently, we found a novel ligand-receptor system that potentially plays a driving role in the aggressiveness of a subset of lung adenocarcinomas. This system, comprising the R-spondin (RSPO) group of secreted proteins as ligands and LGR4 as the receptor, is genetically altered to cause tumor formation in a small fract...

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