Grant ID RP160232
Awarded On November 19, 2015
Title Understanding Biological and Physical Factors Affecting Response to Proton Therapy to Improve its Clinical Effectiveness
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Dragan Mirkovic
Cancer Sites Brain and Other Nervous System, Head and Neck, Lung and Bronchus
Contracted Amount $879,362
Lay Summary

Radiation therapy, often in combination with other modalities, is used in the treatment of nearly two-thirds of the 1.7 million cancers diagnosed annually in the US. Its clinical effectiveness has steadily been improving with the latest advance being proton therapy.In principle, because of their unique physical properties, protons have the potential to be much more effective than the currently prevalent modality of photons. The most advanced, and potentially the most effective form of proton therapy, is intensity-modulated proton therapy (IMPT). IMPT is delivered with thin scanning beams (“beamlets”) of protons.Despite proton therapy’s high promise, clinical evidence of its superiority has b...

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