|Awarded On||November 19, 2015|
|Title||Imaging-based quantitative analysis of vascular perfusion and tissue oxygenation to improve therapy of hepatocellular carcinoma|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Rony Avritscher|
|Cancer Sites||All Sites|
Primary liver cancer is the most rapidly increasing cause of cancer mortality in the United States. Unfortunately, only less than 20% of the patients are candidates for curative surgery. The rest of the patients undergo treatments designed to slow down the disease. Despite recent advances in drugs designed to deprive the tumors from oxygen by inhibiting new blood vessel growth, overall improvement is found to be only temporary. We now understand that cells deprived of oxygen play a central role in tumor growth and treatment failure. Given these new discoveries, areas of low oxygenation in tumors are of great interest in cancer research, including the potential to exploit them during can...