Grant ID RP160192
Awarded On November 19, 2015
Title Decoding Cellular Heterogeneity of Malignant Glioma
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Benjamin Deneen
Cancer Sites Brain and Other Nervous System
Contracted Amount $899,701
Lay Summary

Malignant glioma is the most prevalent form of adult brain cancer, responsible for approximately 12,000 deaths/year, and is exceedingly difficult to manage with an average five-year progression-free survival of <5%. One feature that makes malignant glioma difficult to treat is the extraordinary cellular heterogeneity of the primary tumor mass. This extreme heterogeneity is compounded by the fact that the identities and properties of the diverse cell populations remain undefined. This lack of basic understanding of the cellular constituency of malignant glioma is a major hurdle in the development of new treatments for this mysterious, enigmatic, and deadly disease. Therefore, the goal of t...

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