|Awarded On||November 19, 2015|
|Title||Regulation of infiltration and function of tumor-resident CD8 T cells by IL-15|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Kimberly S Schluns|
|Cancer Sites||All Sites|
Cancer patients vary considerably in their responses to cancer therapies. Recent studies have found that patients with tumors containing cytolytic T cells have significantly better clinical outcomes. This provides evidence that one’s own cytolytic T cells are capable of effective tumor clearance. Unfortunately, it is not clear how sufficient numbers of T cells are generated in tumors. Excitingly, the presence of the T cell growth factor, Interleukin-15 (IL-15) within tumors has recently been shown to be associated with increased T cell numbers within tumor, increased patient survival, and lower rate of relapse. Overall, this is compelling evidence that IL-15 is critical for generating tumor...