Grant ID RP160188
Awarded On November 19, 2015
Title Regulation of infiltration and function of tumor-resident CD8 T cells by IL-15
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Kimberly S Schluns
Cancer Sites All Sites
Contracted Amount $828,060
Lay Summary

Cancer patients vary considerably in their responses to cancer therapies. Recent studies have found that patients with tumors containing cytolytic T cells have significantly better clinical outcomes. This provides evidence that one’s own cytolytic T cells are capable of effective tumor clearance. Unfortunately, it is not clear how sufficient numbers of T cells are generated in tumors. Excitingly, the presence of the T cell growth factor, Interleukin-15 (IL-15) within tumors has recently been shown to be associated with increased T cell numbers within tumor, increased patient survival, and lower rate of relapse. Overall, this is compelling evidence that IL-15 is critical for generating tumor...

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