Grant ID RP160180
Awarded On November 19, 2015
Title Development of Therapeutics Targeting Truncated Adenomatous Polyposis Coli (APC) as a Novel Prevention and Intervention Strategy for Colorectal Cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Jerry W Shay
Cancer Sites Colorectal
Contracted Amount $900,000
Lay Summary

Despite the enormous burdens placed on the U.S. healthcare system, treatments for colorectal cancer (CRC) is primarily reliant upon chemotherapeutic agents that act with minimal specificity for the underlying genetic basis of disease. The adenomatous polyposis coli (APC) gene is specifically altered in ~80% of colon tumors. We have developed a small molecule targeted therapy for the vast majority of CRC patients expressing truncated APC proteins. We have conducted a high-throughput 200,000 small molecule screen and identified a lead compound that shows selective toxicity to human CRC cells expressing a truncated APC protein but not normal human colonic epithelial cells. This lead compound ...

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