Grant ID RP160145
Awarded On November 19, 2015
Title Early Detection of Ovarian Cancer with Tumor Associated Proteins and Autoantibodies
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Prevention and Early Detection
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Robert Bast
Cancer Sites Ovary
Contracted Amount $1,487,303
Lay Summary

Currently available surgery and chemotherapy can cure 90% of women with cancer confined to the ovary (stage I) and 70% with disease limited to the pelvis (stage II). When ovarian cancer has spread further (stage III, IV), cure rates plummet to 20% or less. Ovarian cancer is diagnosed in early stage in only 20-25% of cases. We found that annual measurement of CA125 followed by ultrasound and surgery, if indicated, can detect early stage (I, II) ovarian cancer in 9 of 12 cases (75%). Three operations are required to diagnose each cancer using a mathematical formula (algorithm) that determines whether CA125 is rising. As CA125 is expressed by only 80% of ovarian cancers, additional bio...

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