Grant ID RP160124
Awarded On November 19, 2015
Title Chemoprevention of Colon Cancer by Anti-inflammatory Blockade Using Neem
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Prevention and Early Detection
Institution/Organization The University of Texas Health Science Center at San Antonio
Principal Investigator/Program Director Michael J Wargovich
Cancer Sites Colorectal
Contracted Amount $899,617
Lay Summary

Use of anti-inflammatory drugs appears to protect against the development of colon cancer, yet their long-term use of these agents as cancer preventives is plagued by unacceptable toxicity such as bleeding, ulceration, impaired renal function and heart attacks. Yet targeting chronic inflammation as a colorectal cancer prevention strategy remains very promising, if safer anti-inflammatory agents can be found. From nature, the neem tree, native to India and Africa is highly prized for its anti-inflammatory activity in use as a traditional medicine. Our laboratory has unique access to a highly purified supercritical extract of neem leaf and we have identified a promising lead compound, nimbolid...

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