Grant ID RP160089
Awarded On November 19, 2015
Title Carbamoyl Phosphate Synthase-1: A new metabolic liability in non-small cell lung cancers
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Ralph J DeBerardinis
Cancer Sites Lung and Bronchus
Contracted Amount $900,000
Lay Summary

Lung cancer is the most common cause of cancer-related deaths worldwide and has been highlighted as an area of priority by CPRIT and the Texas Department of State Health Services. Among the various subtypes of non-small cell lung cancer (NSCLC), tumors with mutations in both the oncogene KRAS and the tumor suppressor LKB1 are particularly aggressive. Because both KRAS and LKB1 regulate energy metabolism at the cellular level, we explored whether cells harboring mutations in these two genes have specific metabolic requirements that could be exploited to kill them selectively. We discovered that KRAS/LKB1 NSCLC cells use an unconventional form of metabolism in which the building blocks for DNA...

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