Grant ID RP160023
Awarded On November 19, 2015
Title Investigating the genetic and molecular mechanisms underlying RAS/ERK substrate network
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Swathi Arur
Cancer Sites All Sites
Contracted Amount $900,000
Lay Summary

The RAS-Extracellular regulated kinase (ERK) pathway is critical for normal animal development, coordinating different processes like cell division, cell growth, cell death, and cellfate specification. Alterations in this pathway resulting in too much activity of RAS or ERK results in multiple types of cancers. ERK in turn, controls the different biological processes by controlling proteins, which it phosphorylates. These proteins are ERK targets that need to be phosphorylated to execute specific processes. However, during excessive ERK activation, some or all of these tissue specific ERK targets are also inappropriately phosphorylated, and result in mis-regulation of the processes, probably...

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