Grant ID RP160013
Awarded On November 19, 2015
Title Visualizing T-cell trafficking
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Vikas Kundra
Cancer Sites Skin
Contracted Amount $900,000
Lay Summary

Adoptive T-cell therapy is one of the most exciting avenues against cancer. It has proven efficacy. Progress is focused on improving T-cell tumor targeting to improve trafficking to tumors, preserving T-cell signaling and function, and improving persistence. However, methods for visualizing these events and for predicting response in patients are lacking. Progress has suffered from a dearth of clinically relevant, functional imaging methods for repetitively following immune cell trafficking, clonal expansion and persistence. This proposal will address these key issues for T-cell immunotherapy capitalizing upon designer somatostatin receptor-based reporter technology. No human reporter system...

Read More