Grant ID RP150720
Awarded On May 20, 2015
Title Integrated on-chip networks for investigating exosome-mediated drug expulsion
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization Texas Tech University
Principal Investigator/Program Director Wei Li
Cancer Sites All Sites
Contracted Amount $200,000
Lay Summary

Chemotherapy resistant tumors present a significant challenge to cancer treatments, particularly in the case of aggressive or more advanced forms of cancer (i.e. triple negative breast cancer). Recent studies have demonstrated that a subpopulation of resistant cancer cells expel chemotherapeutic drugs in extracellular compartments using specialized transporters system called “exosome”. The use of exosome-mediated transport in anti-cancer drug expulsion, however, is still unclear due to a lack of systematic and quantitative determination of specific molecule contents inside or attached to the exosomes. Current exosome research has been severely constrained by technical difficulties remain in ...

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