|Awarded On||May 20, 2015|
|Title||Integrated on-chip networks for investigating exosome-mediated drug expulsion|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Texas Tech University|
|Principal Investigator/Program Director||Wei Li|
|Cancer Sites||All Sites|
Chemotherapy resistant tumors present a significant challenge to cancer treatments, particularly in the case of aggressive or more advanced forms of cancer (i.e. triple negative breast cancer). Recent studies have demonstrated that a subpopulation of resistant cancer cells expel chemotherapeutic drugs in extracellular compartments using specialized transporters system called “exosome”. The use of exosome-mediated transport in anti-cancer drug expulsion, however, is still unclear due to a lack of systematic and quantitative determination of specific molecule contents inside or attached to the exosomes. Current exosome research has been severely constrained by technical difficulties remain in ...