|Awarded On||May 20, 2015|
|Title||Biomechanical profiling of migrating brain cancer genotypes in tightly-confined space for drug screening|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The University of Texas at Arlington|
|Principal Investigator/Program Director||Young-tae Kim|
|Cancer Sites||Brain and Other Nervous System|
Infiltrating brain cancer cells pose the single greatest challenge to improving the prognosis for primary brain tumor patients; and treatment that can inhibit migration of brain cancer cells has potential to confine this lethal cancer into a local area, which can be effectively removed by focal radiation and/or surgical methods. Accumulative evidence in recent studies has reported that the biomechanical properties of cancer cells regulate migration characteristics of different types of cancers. Conventional tissue-level techniques measure average elasticity behavior of cells and extra-cellular matrix, causing a loss of pertinent information on heterogeneity. However, significant challenges e...