| Grant ID | RP150711 |
| Awarded On | May 20, 2015 |
| Title | Biomechanical profiling of migrating brain cancer genotypes in tightly-confined space for drug screening |
| Program | Academic Research |
| Award Mechanism | High Impact/High Risk |
| Institution/Organization | The University of Texas at Arlington |
| Principal Investigator/Program Director | Young-tae Kim |
| Cancer Sites | Brain and Other Nervous System |
| Contracted Amount | $199,998 |
| Lay Summary |
Infiltrating brain cancer cells pose the single greatest challenge to improving the prognosis for primary brain tumor patients; and treatment that can inhibit migration of brain cancer cells has potential to confine this lethal cancer into a local area, which can be effectively removed by focal radiation and/or surgical methods. Accumulative evidence in recent studies has reported that the biomechanical properties of cancer cells regulate migration characteristics of different types of cancers. Conventional tissue-level techniques measure average elasticity behavior of cells and extra-cellular matrix, causing a loss of pertinent information on heterogeneity. However, significant challenges e... |