Grant ID RP150711
Awarded On May 20, 2015
Title Biomechanical profiling of migrating brain cancer genotypes in tightly-confined space for drug screening
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas at Arlington
Principal Investigator/Program Director Young-tae Kim
Cancer Sites Brain and Other Nervous System
Contracted Amount $199,998
Lay Summary

Infiltrating brain cancer cells pose the single greatest challenge to improving the prognosis for primary brain tumor patients; and treatment that can inhibit migration of brain cancer cells has potential to confine this lethal cancer into a local area, which can be effectively removed by focal radiation and/or surgical methods. Accumulative evidence in recent studies has reported that the biomechanical properties of cancer cells regulate migration characteristics of different types of cancers. Conventional tissue-level techniques measure average elasticity behavior of cells and extra-cellular matrix, causing a loss of pertinent information on heterogeneity. However, significant challenges e...

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