Grant ID RP150701
Awarded On May 20, 2015
Title Non-invasive Colonoscopy by Molecular Imaging of Mucin Targeted Hyperpolarized Silicon Nanoparticles
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization Rice University
Principal Investigator/Program Director Daniel D Carson
Cancer Sites Colorectal
Contracted Amount $200,000
Lay Summary

A non-invasive, high-definition colonoscopy would benefit diagnosis of colon cancer. Conventional colonoscopy can damage the gut and is often limited by patient tolerance. Virtual colonoscopy, which employs computed tomography or magnetic resonance (MR) scans, is non-invasive, but is limited by radiation exposure, and it cannot detect lesions smaller than 5 mm. The. Bhattacharya laboratory at M. D. Anderson Cancer Center has developed a direct in vivo imaging modality of hyperpolarized silicon nanoparticles (SiNPs) using MR Imaging. Using hyperpolarization, the sensitivity of the conventional MR signal is enhanced over 10,000X. Unlike other hyperpolarized nuclei, the signal from SiNPs is lon...

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