Grant ID RP150696
Awarded On May 20, 2015
Title Inhibition of Breast Cancer Metastasis to the Bone by microRNA Transmission through Gap Junctions
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas Health Science Center at San Antonio
Principal Investigator/Program Director Bruce Nicholson
Cancer Sites Bone, Breast
Contracted Amount $200,000
Lay Summary

1 in 8 women will be diagnosed with breast cancer, with the disease claiming 40,000 lives in the US in 2013, and 10 fold more world-wide. These deaths result mostly from metastasis rather than the primary tumor, with a median survival time under 3 years after first diagnosis of metastatic spread. No effective cure currently exists for the metastatic phase of the disease, leading some high risk women to even contemplate preventative mastectomy! Yet we know that the body does have defenses against the metastatic process, as there are often long latent periods between initial breast cancer diagnosis and manifestation of bone metastases. This is the equivalent of the “soil” trying to reject the ...

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