Grant ID RP150648
Awarded On May 20, 2015
Title GATA2 and steroid receptor coactivator-2 cooperate with androgen receptor in prostate cancer progression and androgen resistance
Program Academic Research
Award Mechanism Multi-Investigator Research Awards (Version 2)
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Bert O'Malley
Cancer Sites Prostate
Contracted Amount $6,151,179
Lay Summary

Prostate Cancer (PC) is typically dependent upon androgen hormones such as testosterone that interact with the androgen receptor (AR) expressed in PC cells. Drugs designed to block AR function or block androgen synthesis in the body are currently being used in the clinic to treat PC. However, PC frequently becomes resistant to these therapeutic interventions, leading to castration-resistant prostate cancer (CRPC), a very aggressive cancer that leads to death. Importantly, CRPCs still express AR regulated genes, suggesting that the AR axis remains active. CRPC achieve resistance by promoting persistent AR axis activation in several ways such as by: 1) overexpressing cell fate-determining tran...

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