|Awarded On||May 20, 2015|
|Title||Efficient Production of iPSC-Derived Mesenchymal Stem Cells to Kill Cancers by Bystander Effects from Suicide Genes|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Texas A&M University System Health Science Center|
|Principal Investigator/Program Director||Thomas Bartosh|
|Cancer Sites||All Sites|
Treatment of cancer is one of the most challenging areas in medicine today. New therapeutic strategies are desperately needed as the incidence of cancer and cancer-related deaths continues to rise. One attractive and promising avenue to effectively eliminate cancer is centered on the ability to introduce suicide or ‘cancer-killing’ genes directly into tumors so that when a cancer patient is given a harmless prodrug, products of the suicide gene will convert the prodrug into a toxic compound that kills the neighboring cancer cells. The success of this approach, often referred to as targeted suicide gene therapy, rests in the ability to deliver the suicide genes exclusively within the tumor ma...