Grant ID RP150574
Awarded On May 20, 2015
Title Turning on a Novel Tumor-Inhibiting Switch for Colorectal Cancer
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas Health Science Center at San Antonio
Principal Investigator/Program Director Rong Li
Cancer Sites Colorectal
Contracted Amount $200,000
Lay Summary

It is known that estrogen is associated with reduced incidence of colorectal cancer (CRC). Estrogen effects in general are mediated by two estrogen receptors called ER-alpha and ER-beta, which play different and even opposite roles in cancer. The CRC-reducing effect of estrogen has been largely attributed to the action of ER-beta. Because estrogen itself is unlikely to be clinically useful due to its known ER-alpha-mediated side effects, rallying the antitumor activity of ER-beta through ER-beta-specific pathways represents a promising approach for CRC treatment and prevention. In the current proposal, researchers with highly complementary expertise will determine whether a clinically safe E...

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