Grant ID RP150498
Awarded On February 18, 2015
Title Harnessing the Cytosolic DNA Sensing Pathway for Cancer Immunotherapy
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Zhijian J Chen
Cancer Sites Lung and Bronchus, Melanoma, Pancreas
Contracted Amount $889,185
Lay Summary

Our immune system protects us not only from infections by pathogens, but also from cancer. Thanks to this powerful and elaborate immune system, most people do not develop cancer and maintain a healthy lifestyle. Unfortunately, some people succumb to cancer in part because their immune system fails to detect or eliminate cancer cells. Thus, one of the most promising strategies to combat cancer is to restore and harness the body’s own immune system to recognize and eradicate cancer cells. This strategy, known as cancer immunotherapy, has recently demonstrated remarkable success in human clinical trials. However, many patients still cannot benefit from the current therapies called the immune ch...

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