Grant ID RP150445
Awarded On February 18, 2015
Title Ewing's sarcoma, a homologous recombination defective disease
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Cancer in Children and Adolescents
Institution/Organization The University of Texas Health Science Center at San Antonio
Principal Investigator/Program Director Alexander Bishop
Cancer Sites Childhood and Adolescent
Contracted Amount $1,979,137
Lay Summary

Ewing’s sarcoma occurs in children and young adults. The standard treatment, that effective 70% of the time, is a mixture of toxic chemotherapeutics and surgery. The toxicity in children is a concern since any damaging effects last a lifetime. Further, no successful alternatives exist beyond this first line treatment. Targeted therapy with less toxicity would be a major benefit, but requires a better understanding of Ewing’s sarcoma. We discovered that Ewing’s sarcoma has a defect in a DNA repair pathway called homologous recombination. This is the same kind of defect found in BRCA1 deficient breast cancer. Those cancers are sensitive to PARP1 inhibitors and so is Ewing’s sarcoma. We believe...

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