|Awarded On||February 18, 2015|
|Title||On the role of DEAR1 in the regulation of cell polarity and progression from DCIS to invasive breast cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Ann Killary|
Ductal carcinoma in situ (DCIS) is one of the earliest forms of preinvasive breast cancer, and one of the most common findings on mammography. There is an urgent need to identify predictive and prognostic markers to identify DCIS with a heightened risk of progression to IDC for which more aggressive surveillance and treatment might be warranted, as well as individuals with favorable prognosis, who might be spared rigorous therapeutic regimens and for whom breast conservation therapy might be the preferred surgical option. To address this clinical issue, it is critical to identify the “drivers” of DCIS to IDC based on the underlying genetic abnormalities and aberrant pathways implicit in the ...