|Awarded On||February 18, 2015|
|Title||Peripheral nerve tolerance to single-session stereotactic irradiation|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Paul Medin|
|Cancer Sites||All Sites|
Stereotactic body radiation therapy (SBRT) is a rapidly expanding treatment modality in which a large dose of radiation is delivered to a tumor in one to five outpatient sessions. SBRT represents a fundamental shift from the traditional approach of Radiation Oncology that embraced protracted fractionation (commonly 25-44 sessions). SBRT is proving effective at tumor control but neural structures in close proximity to tumors are at risk of debilitating toxicity if their radiation dose tolerance levels are exceeded. At least five institutions have reported their experience with peripheral nerve toxicity following SBRT in recent years and our group has managed 11 unreported cases. Very little i...