Grant ID RP150319
Awarded On February 18, 2015
Title Leukemia inhibitory factor receptor signaling and function in cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Li Ma
Cancer Sites Breast, Gallbladder, Liver and Intrahepatic Bile Duct
Contracted Amount $900,000
Lay Summary

Deregulation of signaling pathways that control organ size, such as the AKT-TOR and Hippo-YAP pathways, can lead to tumorigenesis and metastasis. A major barrier in eradicating the death and suffering from breast cancer is the shortage of clinically proven prognostic markers and therapeutic agents for metastasis. Although many breast cancer metastasis-promoting genes have been reported, they have not been translated into clinical benefits except HER2. On the other hand, few genes have been established as metastasis suppressors. Using a high-throughput sequencing approach, our laboratory identified leukemia inhibitory factory receptor (LIFR) as a novel breast cancer metastasis suppressor down...

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