Grant ID RP150242
Awarded On February 18, 2015
Title Functional and structural characterization of a small chemical compound that arrests glioma stem cell growth with high activity and specificity
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Jef K De Brabander
Cancer Sites Brain and Other Nervous System
Contracted Amount $900,000
Lay Summary

Glioblastoma multiforme (GBM) is the most common type of malignant brain cancer and is incurable. Therefore, there is a critical need to identify new ways of investigating and attacking this disease. The Cancer Genome Atlas Project, a multi-institutional effort to study the DNA of cancers in the hopes of finding common mutations that may indicate new targets for developing therapies identified mutation combinations of a dozen or so genes previously associated with cancer in GBM. Of these, three cancer associated genes: p53, NF1 and Pten were among the five most frequently mutated GBM associated genes. We have constructed genetically engineered mice that harbor the above three mutations and t...

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