Grant ID RP150197
Awarded On February 18, 2015
Title Understanding How NCOA6 Suppresses Endometrial Cancer by Inhibiting the Wnt/beta-Catenin Pathway
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Jianming Xu
Cancer Sites Cervix Uteri
Contracted Amount $886,524
Lay Summary

Endometrial cancer (EMC) is a disease with high mortality. Enhanced uterine (U) sensitivity to estrogen (E), activation of the Wnt/beta-catenin (W/bC) pathway and inactivation of the Pten tumor suppressor are main driving forces of EMC. However, it is unknown what controls the U E sensitivity and holds the W/bC activity to prevent EMC. Our preliminary study suggests that NCOA6, a gene expression coregulator, may be a potent suppressor of EMC by inhibiting the U E sensitivity and W/bC activation. We found NCOA6 is frequently mutated in human EMC. Deletion of NCOA6 from mouse uterus increased E sensitivity, activated the W/bC pathway, caused EMC development and accelerated the growth of EMC wi...

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