|Awarded On||February 18, 2015|
|Title||Using imaging and computational tools to improve risk stratification in children with bone cancer|
|Award Mechanism||Individual Investigator Research Awards for Cancer in Children and Adolescents|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Patrick Leavey|
|Cancer Sites||Bone, Childhood and Adolescent, Sarcoma|
Osteosarcoma is the most common bone cancer in children and young adults but at least 40% of patients die of this disease. There is an urgency and critical need to identify accurately and as early as possible those patients at high risk of dying. Basic features of tumor spread and if the tumor is surgically removable identify such patients, while poor tumor response to 10 weeks of chemotherapy is another high-risk feature. Unfortunately identifying these features has not yet allowed effective change in therapy to improve patient survival. Yet, since tumor response in other childhood cancers allows effective tailoring of therapy, we believe that the inability to achieve improvements for patie...