|Awarded On||February 18, 2015|
|Title||Identifying Drivers of Lung Metastasis in Triple Negative Breast Cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Helen Piwnica-Worms|
The process by which breast cancer cells leave the breast and begin to grow and divide in other organs is called metastasis. For reasons that are currently not understood, patients with triple negative breast cancer (TNBC) are prone to develop lung metastases. There are few options for breast cancer patients once tumor cells gain the capacity to leave the breast and take up residence in foreign organs. The major objective of the proposed research is to determine how TNBC cells acquire the capacity to metastasize and grow in the lung. This will be accomplished using a model whereby primary breast cancer cells, obtained directly from patients with TNBC, are grown in mouse mammary glands that h...