|Awarded On||February 18, 2015|
|Title||Investigating the regulation of miRNA and lncRNAs by p63 in mammary tumor progression and metastasis|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Chunru Lin|
Mortality in cancer is most often due to the development of distant metastases for which almost no effective systemic treatments exist. P63, a family member of the tumor suppressor p53, is often used as a prognostic marker for the treatment of breast cancer. The functions of p63 are beginning to be understood in contexts in which p53 function has been well established, including in response to chemotherapy and radiation (Flores et al., Nature, 2002), in tumor suppression and metastasis (Su et al., Nature, 2010), and stem cell maintenance (Su et al., Cell Stem Cell, 2009; Chakravarti et al., PNAS, 2014). The overarching goal of this application is to develop treatments for metastatic breast c...