Grant ID RP150084
Awarded On February 18, 2015
Title Role of PTEN feedback mechanism in cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Min Sup Song
Cancer Sites Breast, Prostate, Thyroid
Contracted Amount $900,000
Lay Summary

Over four decades ago, Alfred G. Knudson proposed a ground-breaking model for tumorigenesis, suggesting that cancer is a consequence of genetic mutations that inactivate specific genes which suppress the growth of cancer cells. This visionary working model has greatly advanced our understanding of cancer, and has directly led to the discovery of numerous tumor suppressor genes, including PTEN (phosphatase and tensin homolog). PTEN was found to be frequently disrupted in multiple sporadic tumor types, and mutated in the germlines of patients with cancer predisposition syndromes such as Cowden disease. PTEN protein is known to govern a plethora of cellular processes, including cell survival, p...

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