|Awarded On||February 18, 2015|
|Title||Genetic susceptibility to testicular germ cell tumors|
|Award Mechanism||Individual Investigator Research Awards for Cancer in Children and Adolescents|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Jason Heaney|
Testicular germ cell tumors (TGCTs) are the most frequent solid tumor diagnosed in boys and young men. TGCTs result from defects in the development of embryonic male germ cells, which normal develop into sperm. TGCTs are treatable by surgery, radiation, and chemotherapy. However, current treatments cause long-term side effects such as mental impairments and infertility. TGCTs may also spread to other organs if not detected early or completely removed. In addition, many TGCTs are resistant to otherwise effective treatment options. Thus, improvements in early diagnosis and treatment remain important, and the social, emotional, and medical costs remain high. The likelihood of an individual deve...