Grant ID RP150006
Awarded On February 18, 2015
Title Defining and Treating Targetable Lesions in AYA Acute Lymphoblastic Leukemia
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Cancer in Children and Adolescents
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Marina Konopleva
Cancer Sites Childhood and Adolescent, Leukemia
Contracted Amount $1,989,950
Lay Summary

Acute lymphoblastic leukemia (ALL) is the most common form of cancer in children. Despite tremendous improvements in the outcomes, a subset of children relapses and often succumbs to their disease. In adults, the outcomes remain vastly inferior, and most patients are expected to die either of their disease or of treatment-related toxicities. The need for novel therapies is thus unquestioned. A major recent advance in understanding the biology of ALL was the discovery of a novel category of “Ph-like” ALL which exhibit gene expression signatures similar to patients with “Philadelphia (Ph)” chromosome but are lacking Ph-chromosome. Further discoveries have demonstrated that the tumors in these ...

Read More