|Awarded On||February 18, 2015|
|Title||Defining and Treating Targetable Lesions in AYA Acute Lymphoblastic Leukemia|
|Award Mechanism||Individual Investigator Research Awards for Cancer in Children and Adolescents|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Marina Konopleva|
|Cancer Sites||Childhood and Adolescent, Leukemia|
Acute lymphoblastic leukemia (ALL) is the most common form of cancer in children. Despite tremendous improvements in the outcomes, a subset of children relapses and often succumbs to their disease. In adults, the outcomes remain vastly inferior, and most patients are expected to die either of their disease or of treatment-related toxicities. The need for novel therapies is thus unquestioned. A major recent advance in understanding the biology of ALL was the discovery of a novel category of “Ph-like” ALL which exhibit gene expression signatures similar to patients with “Philadelphia (Ph)” chromosome but are lacking Ph-chromosome. Further discoveries have demonstrated that the tumors in these ...