Grant ID | RP120390 |
Awarded On | November 02, 2011 |
Title | Control of cross-talk between ovarian cancer cells and the tumor microenvironment |
Program | Academic Research |
Award Mechanism | Individual Investigator |
Institution/Organization | The University of Texas M.D. Anderson Cancer Center |
Principal Investigator/Program Director | Honami Naora |
Cancer Sites | Ovary |
Contracted Amount | $727,029 |
Lay Summary |
Ovarian cancer is called the “silent killer” because this disease progresses throughout the peritoneal cavity in an aggressive, often asymptomatic, manner. Most women who are diagnosed with ovarian cancer have extensive intraperitoneal disease and are rarely cured by conventional chemotherapy. Ovarian cancer cells typically spread by shedding into the peritoneal fluid and attach to surfaces in the peritoneal cavity, particularly the omentum. The omentum is composed of mesothelial cells that line connective (fibroblastic) and fatty (adipose) tissues, and suspends over the intestines. Growth of tumors on the omentum often results in fatal bowel obstruction. Our proposal investigates the mechan... |