| Grant ID | RP120380 |
| Awarded On | November 02, 2011 |
| Title | Distinct microRNAs Regulate Prostate Cancer Stem Cells |
| Program | Academic Research |
| Award Mechanism | Individual Investigator |
| Institution/Organization | The University of Texas M.D. Anderson Cancer Center |
| Principal Investigator/Program Director | Dean G Tang |
| Cancer Sites | Prostate |
| Contracted Amount | $750,000 |
| Lay Summary |
This project aims to elucidate how three miRNAs (i.e., miR-34a, miR-141, and let-7b) regulate prostate cancer stem cells, which intrinsically express low levels of androgen receptor, are relatively undifferentiated, and may represent important cells of origin for castration-resistant prostate cancer. Our ultimate goal is, through studies such as those proposed herein, to translate key miRNAs functionally important for prostate cancer stem cells into clinical therapeutics against advanced, castration-resistant diseases. |