| Grant ID | RP110028 |
| Awarded On | October 29, 2010 |
| Title | Role of DNA Methylgransferase 3B in normal and malignant hematopoiesis |
| Program | Academic Research |
| Award Mechanism | Individual Investigator |
| Institution/Organization | Baylor College of Medicine |
| Principal Investigator/Program Director | Margaret A Goodell |
| Cancer Sites | Leukemia |
| Contracted Amount | $1,486,780 |
| Lay Summary |
Overwhelming evidence has associated changes in DNA methylation with malignancies, supporting the recent use of new so-called “epigenetic therapies” for some cancers. While these drugs have some efficacy, we understand only poorly how these work, and how to improve them. We will study mice that are deficient for an enzyme which methylates DNA, in order to understand what the role of the DNA methylation is in normal blood-forming stem cells. We will also study the role of this DNA methylation enzyme in generating mouse tumors, by introducing a cancer-causing gene into mice in which the DNA methylase is deleted or mutated. We will then examine the impact on both cancer development as well a... |