| Grant ID | RP101075 |
| Awarded On | June 18, 2010 |
| Title | Identification of a Novel Oncogene in Clear-Cell Renal Cell Carcinoma |
| Program | Academic Research |
| Award Mechanism | Individual Investigator |
| Institution/Organization | The University of Texas Southwestern Medical Center |
| Principal Investigator/Program Director | James Brugarolas |
| Cancer Sites | Kidney and Renal Pelvis |
| Contracted Amount | $1,202,854 |
| Lay Summary |
Kidney cancer is predicted to have been diagnosed in over 50,000 individuals in the US in 2009. In Texas, kidney cancer is the 6th most commonly diagnosed cancer. While up until 2006 only one drug was approved by the FDA for kidney cancer treatment, advances in our understanding of the genetics and the biology of this disease have led to the development and approval of 6 new drugs. These advances resulted from the discovery of two abnormally regulated pathways/genes. However, despite the progress, metastatic kidney cancer remains largely incurable. The identification of new genes deregulated in kidney cancer may lead to the development of new treatments. Based on other tumor types, it is es... |