| Grant ID | R1005 |
| Awarded On | June 18, 2010 |
| Title | Recruitment of Rising Stars |
| Program | CPRIT Scholar |
| Award Mechanism | Recruitment of Rising Stars |
| Institution/Organization | The University of Texas M.D. Anderson Cancer Center |
| Principal Investigator/Program Director | Jessica Tyler |
| Cancer Sites | Multiple Sites |
| Contracted Amount | $3,500,000 |
| Summary of Goals and Objectives |
Our current and future research focus stems from our published and unpublished work on how and why chromatin is assembled and disassembled during transcription, replication, and repair and the implications for the human diseases of cancer and aging. The histone components of chromatin that carry epigenetic information are the most highly conserved proteins in all nature. This enables us to use a variety of eukaryotic systems to discover and study novel mechanisms of epigenetic regulation. Our studies to date have used the powerful combination of yeast genetics, cell biology, biophysics, biochemistry, structural biology and genomic approaches. We will continue to utilize this comprehensiv... |