7 Hills Pharma is a Texas-based company developing novel therapies for cancer. Our drug, 7HP935, could benefit patients with leukemia, who require stem cell transplant. The curative potential of transplant is limited by timely access to a suitable donor and elevated risk of infection, particularly in Hispanic/Latino and Black patients, who comprise 51.8% of the Texas population. Umbilical cord blood (UCB) is a readily available, FDA approved stem cell source that has been shown to have curative potential but is limited by slow stem cell engraftment, resulting in high infection rates and extended hospital stays. 7HP935 is a potential drug that, given in combination with a stem cell transplan...

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7 Hills Pharma is a Texas-based company developing novel therapies for cancer. Our drug, 7HP935, could benefit patients with leukemia, who require stem cell transplant. The curative potential of transplant is limited by timely access to a suitable donor and elevated risk of infection, particularly in Hispanic/Latino and Black patients, who comprise 51.8% of the Texas population. Umbilical cord blood (UCB) is a readily available, FDA approved stem cell source that has been shown to have curative potential but is limited by slow stem cell engraftment, resulting in high infection rates and extended hospital stays. 7HP935 is a potential drug that, given in combination with a stem cell transplant, could improve these limitations and, importantly, decrease racial disparities and increase access to curative therapy. This proposal aligns with CPRIT's mission to bring accessible treatment options to cancer patients, particularly to those in Texas. The requested CPRIT funds will enable completion of Phase I safety testing in healthy subjects and lay the foundation to test 7HP935 in patients with leukemia. If successful, these studies may represent a new treatment paradigm for patients with leukemia that could deliver the curative promise of stem cell transplant. 7 Hills will expand operations in Houston, creating high-quality jobs in drug development and clinical operations. 7 Hills is committed to Texas and will ensure that CPRIT funds are spent in Texas, whenever possible.

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