Grant ID DP240075
Awarded On November 15, 2023
Title Mongoose Bio Memory TCR-T Cell Discovery and Therapeutics for Empirically Validated Tumor Targets
Program Product Development Research
Award Mechanism Texas New Technologies Company Awards for Product Development Research
Institution/Organization Mongoose Bio, LLC
Principal Investigator/Program Director Cassian Yee
Cancer Sites Esophagus, Lung and Bronchus
Contracted Amount $10,621,053*

*Pending contract negotiation

Lay Summary

Mongoose Bio is an early-stage clinical company pioneering groundbreaking, precision T-cell based therapies targeting solid cancers. Our T cell receptor (TCR)-based lead product is the HORMAD1 Central Memory T cell, which is highly immunogenic and broadly expressed in many solid tumors. It was identified using a proprietary patented mass spec (MS)-based immunopeptidome discovery platform (IDP) that is unbiased, physiologically relevant, and clinically validated to target pan cancers. This revolutionary adoptive T-cell therapy is the result of 17+ years of pioneering work from Mongoose Bio founder Dr. Cassian Yee and his lab at the MD Anderson Cancer Center (MDACC). In addition to IDP-driven ...

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