Grant ID DP220039
Awarded On August 17, 2022
Title Single Dose 186RNL for Leptomeningeal Metastases: Multicenter Phase 1/2a Study to Determine MTD/MFD, Safety & Efficacy, Leading to Pivotal Registrational Trial
Program Product Development Research
Award Mechanism Texas Company Product Development Awards
Institution/Organization PLUS Therapeutics, Inc.
Principal Investigator/Program Director Norman LaFrance
Cancer Sites Breast, Lung and Bronchus, Skin
Contracted Amount $17,613,605
Lay Summary

PLUS Therapeutics' Rhenium-186 NanoLiposome (186RNL) is a novel radiotherapeutic being developed to combat rare and difficult-to-treat cancers. Currently in clinical development for recurrent glioblastoma, 186RNL is safe and well-tolerated while delivering a radiation dose to the tumor that is up to 15 times higher than typically achievable with standard radiation therapy. PLUS now plans to develop 186RNL to treat leptomeningeal metastases (LM), a rare but typically fatal complication of advanced cancer affecting the fluid-lined structures surrounding the brain and spinal cord. LM affects over 110,000 people in the U.S. every year and, even with the best available care, is rapidly fatal with...

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