Grant ID DP150094
Awarded On November 19, 2014
Title Genetic engineering of T cells as an “off-the-shelf” therapy for leukemias and lymphomas
Program Academic Research
Award Mechanism Bridging the Gap: Early Translational Research Awards
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Laurence Cooper
Cancer Sites Leukemia, Lymphoma
Contracted Amount $1,992,245
Lay Summary

T cells are a part of the immune system responsible for attacking and destroying tumor cells. Patient-specific cells can be manipulated in the laboratory to redefine specificity and improve potency. This is achieved by combining gene therapy with immunotherapy. However, these laboratory procedures take time during which the patient’s underlying medical condition can deteriorate robbing them of the chance to receive immunotherapy.

Therefore, we developed an approach whereby gene therapy can be used to manipulate T cells before a patient needs them. These T cells can then be frozen in banks and thawed and infused when the patient requires, rather than when the cells are available. This CPRIT a...

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