Grant ID DP150083
Awarded On November 19, 2014
Title NKT Cell Platform for Cancer Immunotherapy
Program Academic Research
Award Mechanism Bridging the Gap: Early Translational Research Awards
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Leonid S Metelitsa
Cancer Sites All Sites
Contracted Amount $1,928,220
Lay Summary

The goal of this project is to develop a new class of cancer immunotherapy that exploits natural and engineered properties of Natural Killer T cells (NKTs) to target tumor-supportive stroma. Increasing numbers of clinical trials using adoptive T cell therapies are showing anti-tumor activity against a broad range of malignancies. However, tumor growth creates a highly immunosuppressive stroma which impairs T-cell homing to the tumor site or their anti-tumor function. This represents a major and as yet unsolved critical challenge to the development of effective adoptive immunotherapy of cancer.

The proposed project will develop banked or “off-the-shelf” NKTs engineered to express the cytokine...

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