Grant ID DP150077
Awarded On November 19, 2014
Title Targeting the SWI/SNF chromatin-remodeling complex in liver cirrhosis and hepatocellular carcinoma
Program Academic Research
Award Mechanism Bridging the Gap: Early Translational Research Awards
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Hao Zhu
Cancer Sites Gallbladder, Liver and Intrahepatic Bile Duct
Contracted Amount $1,357,880
Lay Summary

Hepatocellular carcinoma (HCC) is a significant cause of cancer-related death worldwide and Texas has the second highest HCC incidence rate in the US. Cirrhosis is the strongest risk factor for HCC, and without cirrhosis, there would be few cases of HCC. Thus, the challenge is twofold: 1) to develop effective therapies for cirrhosis, and 2), to develop effective HCC drugs that do not harm the cirrhotic liver.

Recently, we identified a pathway that when suppressed, results in better liver regeneration and can potentially inhibit HCC. Mice defective for a gene called Arid1a, part of the SWI/SNF gene family that normally regulates the physical scaffold of the genome, showed increased liver cell...

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