Grant ID DP150055
Awarded On November 19, 2014
Title Druggable Targets that Regulate the Antitumor Activity of ER-beta
Program Academic Research
Award Mechanism Bridging the Gap: Early Translational Research Awards
Institution/Organization The University of Texas Health Science Center at San Antonio
Principal Investigator/Program Director Rong Li
Cancer Sites Breast
Contracted Amount $1,998,444
Lay Summary

Estrogen Receptor beta (ER-beta) is often viewed as the “Cinderella sister” of ER-alpha with just the “opposite personality”. Unlike ER-alpha that has the known tumor-promoting activity, ER-beta has an antitumor activity in breast cancer. Because ER-beta is present in as many as half of all breast cancer cases, rallying its tumor-inhibitory activity is an attractive therapeutic strategy. However, this therapeutic potential of ER-beta has been largely untapped.

The current proposal, which is aimed at mobilizing the antitumor activity of ER-beta, is based on two recent exciting developments in ER-beta research. First, a highly potent ER-beta-specific activator was shown recently to be clinica...

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