|Awarded On||August 18, 2021|
|Title||Role of Aberrant Translational Quality Control in Tumorigenesis of Glioblastoma|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Southern Methodist University|
|Principal Investigator/Program Director||Zhihao Wu|
|Cancer Sites||Brain and Other Nervous System|
Mitochondria are the cellular organs that generate energy using oxygen. Glioblastoma (GBM) is aggressive cancer without a cure. Due to their rapid proliferation, GBM cells need to adapt to a low oxygen environment. They do so by altering normal mitochondrial functions. One adaptation is an increased concentration of proton outside the inner mitochondrial membrane, referred to as high membrane potential, which has been shown to be critical for tumor growth. Therefore, reducing mitochondrial membrane potential may be a promising novel approach to treat GBM. However, it is unclear how GBM maintains a higher than normal mitochondrial membrane potential which normally is generated by concentratin...