Grant ID R1003
Awarded On June 18, 2010
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization The University of Texas at Austin
Principal Investigator/Program Director Lauren Ehrlich
Cancer Sites Leukemia, Multiple Sites
Contracted Amount $2,000,000
Lay Summary

T cell acute lymphoblastic leukemia (T-ALL) arises from developing T cells, occurs predominantly in children and adolescents, and represents ~15% of pediatric ALL cases. The use of intensified chemotherapy regimens has improved the 5-year event free survival to 75-83%. However, non-responding patients have poor outcomes.

Since the central nervous system is frequently a site of relapse, T-ALL patients often receive cranial irradiation, resulting in adverse effects such as impaired cognitive development and secondary tumors. Therefore, development of targeted therapies resulting in less short-term toxicity, a higher percentage of clinical response, and reduced long-term morbidity, would addres...

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