Srinivas Malladi, Ph.D.
The University of Texas Southwestern Medical Center
|Titles & Positions|
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|Grant ID: RR170003|
Recruitment of First-Time, Tenure-Track Faculty Members
Memorial Sloan-Kettering Cancer Center
November 16, 2016
Many cancers that initially respond to therapy later relapse as metastatic disease, with the cancer widely spread throughout a patient’s body. The cells that seed these dispersed sites can remain in a quiescent state for months or even years before roaring back to life and producing cancer even more intransigent to treatment. Distant metastases underlie more than 90 percent of deaths from cancer.
Understanding the molecular underpinnings of how these latent cancer cells evade the immune system, as well as cancer therapy, has the potential to transform cancer medicine.