Grant ID RR220081
Awarded On May 18, 2022
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization Baylor University
Principal Investigator/Program Director Jonathan Clinger
Cancer Sites All Sites
Contracted Amount $1,998,029
Summary of Goals and Objectives

This proposal utilizes time-resolved and multi-temperature crystallography of polyamine biosynthesis enzymes: ornithine decarboxylase (ODC), spermidine synthase (SPDS), and spermine synthase (SPS) to improve the structural knowledgebase of these enzymes for dynamic structure-based inhibitor design. These enzymes are upregulated in aggressive hepatocellular carcinomas and in childhood neuroblastomas, and ODC provides feedback to the oncogene myc. However, only ODC has an FDA approved inhibitor, and high-throughput inhibitor screening of these enzymes has proven challenging due to the lack of development of applicable assays. Time-resolved crystallography, utilizing the recently developed Mill...

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