|Awarded On||August 16, 2017|
|Title||Establish a New Cryo-Electron Microscopy Core Facility and Service for Structure Determination at UT Southwestern Medical Center|
|Award Mechanism||Core Facility Support Awards|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Daniela Nicastro|
|Cancer Sites||All Sites|
Understanding the causes of cancer and identifying treatments for this devastating disease require knowledge of the cellular machineries (protein complexes) that are the drivers of tumor initiation, progression and metastasis. Determining the three-dimensional structures of these machineries is essential to understanding the mechanisms of cancer, identifying drug targets and developing therapeutics. Recent revolutionary advances have rendered cryo-electron microscopy (cryo-EM) the method of choice for determining protein structures in detail, i.e. at the level of individual atoms; while cryo-electron tomography (cryo-ET) enables these molecular machines to be viewed inside cells. UT Southwes...